These substances , Aicar , GW-501516, and RAD 150, frequently mentioned in the bodybuilding community, warrant a thorough review. AICAR acts as an AMPK trigger, enhancing glucose uptake and fatty acid oxidation. GW-501516, often called Cardarine, is a PPARδ activator believed to promote endurance and lipids loss . RAD 150, or S4, is an SARM design